Refuting Myths About Carrageenan

Recent resurrection of a link between carrageenan and poligeenan (and the latter's connection to cancer) are unfounded.

By Harris Bixler, Ingredients Solutions Inc.

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Editor's Note: There has been some Internet discussion in recent weeks reviving a connection between carrageenan, the colloid sourced from seaweed, and poligeenan, which studies find to be a possible carcinogen. The connection was first established by Joanne Tobacman, an associate professor at the University of Illinois in Chicago, whose research found "harmful effects of … carrageenan on human intestinal cells." She filed a petition with the FDA in 2008 asking a revocation of carrageenan's use as a food additive, but the FDA denied her petition in June of 2012. She also unsuccessfully lobbied the National Organic Standards Board. The subject has been revived by bloggers and others. Ingredients Solutions Inc., one supplier of carrageenan-based hydrocolloids, offers this refutation.

Carrageenan is a naturally occurring seaweed extract. It is widely used in foods and non-foods to improve texture and stability. Common uses include meat and poultry, dairy products, canned pet food, cosmetics and toothpaste.

Self-appointed consumer watchdogs have produced numerous web pages filled with words condemning carrageenan as an unsafe food additive for human consumption. However, in 70-plus years of carrageenan being used in processed foods, not a single substantiated claim of an acute or chronic disease has been reported as arising from carrageenan consumption.

On a more science-based footing, food regulatory agencies in the U.S., the European Union and the United Nation's Food and Agriculture Organization/World Health Organization (FAO/WHO) repeatedly review and continue to approve carrageenan as a safe food additive.

What led up to this misrepresentation of the safety of an important food stabilizer, gelling agent and thickener? It clearly has to be attributed to the research of Dr. Joanne Tobacman, an associate professor at the University of Illinois in Chicago. She and a group of molecular biologists have accused carrageenan of being a potential inflammatory agent as a conclusion from laboratory experiments with cells of the digestive tract.

It requires a lot of unproven assumptions to even suggest that consumption of carrageenan in the human diet causes inflammatory diseases of the digestive tract. The objectivity of the Chicago research is also flawed by the fact that Dr Tobacman has tried to have carrageenan declared an unsafe food additive on weak technical arguments that she broadcast widely a decade before the University of Chicago research began.

Poligeenan ("degraded carrageenan" in pre-1988 scientific and regulatory publications) is a possible carcinogen to humans; carrageenan is not. The only relationship between carrageenan and poligeenan is that the former is the starting material to make the latter. Poligeenan is not a component of carrageenan and cannot be produced in the digestive tract from carrageenan-containing foods.

There are important differences between poligeenan and carrageenan. The production process for poligeenan requires treating carrageenan with strong acid at high temperature (about that of boiling water) for six hours or more. These severe processing conditions convert the long chains of carrageenan to much shorter ones: 10 to 100 times shorter. In scientific terms the molecular weight of poligeenan is 10,000 to 20,000; whereas that of carrageenan is 200,000 to 800,000.

Concern has been raised about the amount of material in carrageenan with molecular weight less than 50,000. The actual amount (well under 1 percent) cannot even be detected accurately with current technology. Certainly it presents no threat to human health.

There is great importance in these molecular weight differences. Poligeenan contains a fraction of material low enough in molecular weight that it can penetrate the walls of the digestive tract and enter the blood stream. The molecular weight of carrageenan is high enough that this penetration is impossible.

Animal feeding studies starting in the 1960s have demonstrated that once the low molecular weight fraction of poligeenan enters the blood stream in large enough amounts, pre-cancerous lesions begin to form. These lesions are not observed in animals fed with a food containing carrageenan.

Carrageenan passes through the digestive system intact, much like food fiber. In fact, carrageenan is a combination of soluble and insoluble nutritional fiber, though its use level in foods is so low as not to be a significant source of fiber in the diet.

In summary, carrageenan has been proven completely safe for consumption. And poligeenan is not a component of carrageenan.

The consumer watchdogs with their blogs and websites would do far more service to consumers by researching their sources and presenting only what can be substantiated by good science. Unfortunately we are in an era of media frenzy that rewards controversy.

This article originally appeared in the April 2013 issue of Food Processing Magazine.

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